ABSTRACT
Objective To evaluate the in vitro antibacterial activity of 12 antibacterial agents against clinically isolated Propionibacterium acnes (P.acnes).Methods Totally,100 strains of P.acnes were clinically isolated from Institute of Dermatology,Chinese Academy of Medical Sciences and Peking Union Medical College between August 2014 and April 2016.A broth dilution method was used to investigate the sensitivity rate of P.acnes isolates to 12 antibacterial agents including tetracycline,doxycycline,minocycline,erythromycin,roxithromycin,clarithromycin,azithromycin,trimethoprim,levofloxacin,chloramphenicol,clindamycin and fusidic acid,and determine the minimal inhibitory concentration (MIC) of the 12 antibacterial agents against P.acnes isolates.Results The MIC90 values of minocycline,doxycycline,levofloxacin,chloramphenicol,clindamycin,fusidic acid and tetracycline against P.acnes were 8,32,16,128,＞ 128,16 and ＞ 128 mg/L,respectively,and the sensitivity rates of P.acnes to the 7 antibacterial agents were 66％,36％,34％,17％,7％,6％ and 4％ respectively.Trimethoprim and azithromycin showed the MIC90 value of ＞ 128 mg/L and sensitivity rate of 3％.Erythromycin,roxithromycin and clarithromycin showed the MIC90 value of ＞ 128 mg/L and sensitivity rate of 0.Conclusion The clinically isolated P.acnes strains showed the highest sensitivity to minocycline,followed by doxycycline,levofloxacin,chloramphenicol,clindamycin,fusidic acid,tetracycline,trimethoprim and azithromycin,and were resistant to erythromycin,roxithromycin,and clarithromycin.
ABSTRACT
Objective To evaluate the effects of group medical visits and peer education on the compliance behaviors of patients with acne vulgaris,and to explore the effective health education approaches for patients with acne vulgaris.Methods A total of 80 patients with acne vulgaris were enrolled from Hospital of Dermatology,Chinese Academy of Medical Sciences during December 2016.They were randomly and equally divided into 2 groups:intervention group receiving conventional health education combined with group medical visits and peer education,and control group receiving conventional health education alone.At week 1,2 and 4 after the intervention,the compliance behaviors were compared between the 2 groups.Results Totally,18 patients were lost to the follow-up due to refusals and non-response,and 32 patients in the intervention group and 30 patients in the control group finally completed the study.At week 1,2 and 4 after the intervention,the scores of compliance behaviors were significantly higher in the intervention group (83.6 ± 9.3,85.9 ± 9.1,91.2 ± 8.4 respectively) than in the control group (77.1 ± 7.3,77.1 ± 8.6,79.1 ± 10.2 respectively;all P ＜ 0.05).Moreover,the scores of compliance behaviors significantly increased over time (P ＜ 0.05),and there was a significant interaction effect between the intervention methods and treatment duration (P ＜ 0.05).Conclusion Health education approaches including group medical visits and peer education can improve the compliance behaviors of patients with acne vulgaris.